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Antioxidant supplement helps cystic fibrosis patients, study finds

Researchers at Children’s Hospital Colorado (Children’s Colorado) and the University of Colorado School of Medicine have found that taking a specially formulated antioxidant-enriched multivitamin may decrease respiratory illnesses in people with cystic fibrosis (CF).

The study, which was recently published online in the American Journal of Respiratory and Critical Care Medicine, looked at the effects of a ‘cocktail’ of multiple antioxidants on inflammation and health outcomes in patients with CF. Inflammation is an important contributor to lung damage in CF, and contributes to progressive lung function decline.

The 16-week study consisted of 73 pancreatic-insufficient CF patients ages 10 years and older (average age 22 years). These patients ordinarily do not adequately absorb important dietary antioxidants including carotenoids such as beta(β)-carotene, tocopherols (vitamin E), coenzyme Q10 (CoQ10), and selenium that help to neutralize inflammation in the body. To address this issue, the antioxidants used in the study were delivered in a capsule specifically designed for individuals with difficulties absorbing fats and proteins, including those with CF.

Scott D. Sagel
Scott D. Sagel, MD, PhD, pediatric pulmonologist at Children’s Colorado

Antioxidant supplementation was safe and well-tolerated. Supplemental antioxidants increased antioxidant concentrations in the bloodstream in treated subjects and temporarily reduced inflammation in the blood at four weeks but not 16 weeks. Importantly, antioxidant treatment appeared to both prolong the time to the first respiratory illness requiring antibiotics and reduce the frequency of respiratory illnesses they experienced.

Specifically, half as many of the patients taking the supplemental antioxidants experienced a pulmonary exacerbation (or respiratory illness) requiring antibiotics compared to the group taking the control multivitamin without added antioxidants at 16 weeks. In addition, the antioxidant treated group experienced a lower frequency of respiratory illnesses compared to the control group.

“Single oral antioxidant formulations have been previously tested in CF with mixed results. However, there had not been a well-designed, randomized controlled trial of an antioxidant ‘cocktail’ that included multiple antioxidants in a single formulation,” said Scott D. Sagel, MD, PhD, pediatric pulmonologist at Children’s Colorado and professor of pediatrics at the University of Colorado School of Medicine. “While more research certainly needs to be done to find a treatment that delivers a sustained anti-inflammatory effect, we believe the fact that this antioxidant supplement prolonged the time patients had before their first illness is meaningful. It offers a simple, relatively inexpensive means for restoring and maintaining normal antioxidant levels in people who would otherwise have trouble doing so.”

This clinical trial, funded by a grant from the Cystic Fibrosis Foundation, was designed and led by Dr. Sagel. It was conducted from September 2013 to October 2015 at 15 CF centers across the U.S. affiliated with the CF Foundation Therapeutics Development Network.

Guest contributors: Mark Couch, CU School of Medicine, and Hollon Kohtz, Children’s Hospital Colorado.

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An Epic Sprint to aid clinics

In February 2011, the University of Colorado Anschutz Medical Campus took a major step toward fundamentally changing its health care delivery. The change would eventually affect every provider, researcher and staff member on the campus and beyond – and the reverberations continue today.

The revolution began with a handful of ambulatory clinics at University of Colorado Hospital that began using the Epic electronic health record (EHR). The aim: shelve dozens of discrete applications and towering paper stacks in favor of a single system that would allow all providers to view a patient’s entire medical record online.

Sprint Team Conference Room
Sprint team at work near the end of its four weeks of work in the OB/Gyn Clinic.

The Epic implementation included a massive training effort and a phased, multi-year rollout that ensconced the EHR on the Anschutz Medical Campus and at UCH satellite clinics. With the formation and growth of UCHealth, Epic now links hospitals and clinics up and down the Front Range and beyond.

But the challenges of ­working efficiently and effectively with an EHR remain. Memorizing sequences of clicks in record charting can be frustrating for providers focused on patient care. Patients now have an electronic conduit to their providers through My Health Connection; figuring out how best to route and respond to questions can be challenging and time-consuming for clinics. The basic Epic framework requires ongoing customization to meet the needs of dozens of specialists and subspecialists – most them with the CU School of Medicine – and their UCHealth patients.

These challenges help to explain why Epic training, in the form of tip sheets, webinars, emails, and other support, has never ended. The past year has produced a new twist: a dedicated team that gives clinic providers and staff focused, face-to-face help with making the most of the EHR.

On the run

The Sprint team, as it’s called, consists of Epic analysts, trainers, and a project manager, as well as a nurse and physicians who combine clinical and information technology skills. Together they help to define the clinical and operational needs of providers and staff and collaborate with IT, clinical and other experts to meet them. Their guiding principle: people learn best when they have face-to-face help from people who are interested in listening to them, answering their questions and solving their problems.

“It’s a collaborative effort,” said Christine Gonzalez, the Sprint team’s project manager. “When you need to make rapid changes, nothing beats live help. Providers and staff feel safe with working one-on-one.”

The Sprint team is a response to a problem that is both local and national, said Amber Sieja, MD, a physician informaticist for the Anschutz Medical Campus and an internist with the CU School of Medicine. Maintaining paper medical records might have been cumbersome, but for many providers meeting the demands of an electronic system has made practicing medicine more difficult than ever.

“The problem we face is that providers are burned out with their clinical practice,” Sieja said. She noted that in national surveys, providers routinely identify EHRs as a major contributor to that problem. “Locally, our providers have told us the EHR takes up too much time,” she added. “That’s our problem to solve.”

That’s a tall order, however. Epic is a dynamic tool that receives annual upgrades as well as ongoing customized changes for specific clinical areas. How to communicate the changes to the couple of thousand providers with the School of Medicine and UCHealth Medical Group? The Epic team has tried spreading the word with regularly scheduled Skype videos, newsletters, tip sheets, and open training sessions. It’s all fallen well short of reaching anywhere near most providers, Sieja said.

“The message we got is ‘we want somebody in our clinics,’” she said.

Face time

Sprint Team
Members of the Epic Sprint team outside the OB/Gyn Clinic at University of Colorado Hospital. Left to right, back row: Amber Sieja, MD – physician informaticist; Todd Andrews – lead analyst; Dan Golightly – analyst; Rob Lewis – analyst; Dan Kroening – trainer; Diane Pruitt, RN – clinical informaticist. Left to right, front row: Scott Carpenter – lead trainer; Barbara Noble – trainer; Christine Gonzalez – project manager; Megan Cortez – analyst; Tally Talyai, PA – physician informaticist.

That demand spurred the creation of the first “Sprint” in 2016. Sieja, fellow physician informaticist Katie Markley, MD, and UCHealth Chief Medical Information Officer CT Lin, MD, put together a team that parachuted into the Endocrinology Clinic at UCH for a two-week, hands-on helping stint. Their work drew praise from both providers and staff for helping to decrease burnout, reduce charting time and improve patient care.

The Endocrinology pilot wasn’t perfect, Sieja said. Most importantly, it showed that future Sprint projects would need more lead time to prioritize clinic needs, schedule rooms and meeting times, identify potential new EHR builds, and so on. They settled on 90 days of preparation, said Sieja, who used that time to develop a curriculum for the Neurology Clinic at UCH.

The Sprint project in Neuro, which began in January 2017, represented a major challenge. Its nearly 100 providers handled more than 26,000 patient visits in 2016. It also includes eight subspecialties, all with specific patient care needs. A major part of the work involved meeting with “clinical content leaders” to identify priorities for new Epic builds, such as flowsheets to help ensure that patients with neuromuscular diseases like ALS (amyotrophic lateral sclerosis, or Lou Gehrig’s disease) and other complex neurologic conditions receive evidence-based standards of care.

“These are tools that allow us to track patients over time,” said Laura Strom, MD, an epilepsy specialist who helped to lead the Sprint effort in the Neurology Clinic. “They are invaluable in Epic.” The flowsheets, however, had to be built from scratch, a time-consuming process, she added. All told, seven subspecialties requested and received customized builds as part of the Sprint project.

The Sprint team spent a pair of two-week stints, separated by a one-week break, in the Neurology Clinic, wrapping up the work in February. Much of the effort focused on helping providers use Epic more efficiently for their basic work: pulling needed information from patient charts; ordering labs, imaging studies and other tests; responding to patient questions and referral requests; and preparing to address patients’ chief complaints in advance of the visit. Providers learned to use templates, preference lists, keywords and phrases, and other shortcuts to reduce the number of clicks – and therefore time – they spend at the keyboard, Sieja said.

Making work simpler

The key is to reduce frustration with practical help, said Gonzalez, who handles the planning, coordination and other logistical details of each Sprint mission.

“I feel we come in to take a good tool [Epic] that we already have and make it better,” Gonzalez said. Many providers on the Anschutz Medical Campus, she noted, have not had additional guidance in using Epic since the first go-live six-plus years ago.

“Who doesn’t need more training?” Gonzalez asked. She cited the example of a UCHealth Colorado Springs provider who was surprised when she found how much time she could save by using Epic’s Dragon voice-recognition software for her progress notes instead of typing. The shortcut helped her get home to her family earlier.

“She told us the change helped her to become a better mother,” Gonzalez said.

Strom said more than 90 percent of the Neurology Clinic’s providers received the Sprint training in some form. The attention generally helped to increase individuals’ confidence in using shortcuts in Epic to trim their documentation time, she said. One example: “dictionaries” Epic uses to translate shorthand for frequently used terms into the real word.

“People applauded the one-on-one teaching,” Strom said. Some critics of Epic who had viewed it as nothing more than a “billing tool,” she added, changed their minds after the Sprint initiative.

“They saw that Epic could be used to take better care of patients and to help to improve the growth of understanding about their disease,” Strom said. A post-intervention survey showed that both providers and staff viewed Epic in a more favorable light than they had before the Sprint team worked with them. For example, the percentages of those who agreed that the clinic improved its use of the EHR and the patient care it provided increased significantly in both groups.

The Sprint team followed the Neurology Clinic assignment with a regular schedule of visits to UCHealth facilities in Northern and Southern Colorado as well as the Anschutz Medical Campus. For example, they worked with the respective Hematology/Oncology practices at UCHealth’s Memorial Hospital in Colorado Springs and Poudre Valley Hospital in Fort Collins. They wrapped up a four-week stint with the OB/Gyn Clinic at UCH – another with close to 100 providers and several subspecialties – on July 21. They are booked on a two-week on, one-week off schedule through June 2018 (with some extra time off for the next Epic upgrade this October), Gonzalez said.

Important challenges remain, including how to ensure that the positive changes in clinics visited by Sprint continue. Sieja points to the importance of super users and clinical content leaders to “carry the improvements forward.” Sprint success also brings to light questions of “scalability,” said Chief Medical Information Officer Lin, noting that it could be increasingly difficult for a single Sprint team to meet clinic demand. For now, the team splits to work with clinics with fewer providers and subspecialists.

“We need people to bring along others at the basic level,” Strom agreed. “But the sense of what is possible with Epic is now much more keen. More people are saying, ‘We really can use this tool.’”

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CU-provided health care takes soccer by Storm

As injuries in youth soccer grow in severity and numbers, medical personnel are now essential staff for competitive leagues and sports complexes.

A recent national study shows that for every 10,000 youth soccer players in 2014, 223 of them sustained an injury requiring hospital emergency room treatment. That’s a 74 percent increase from 2004, according to the study, which uses data from the National Electronic Injury Surveillance System and the National Sporting Goods Association. Higher levels of youth competition, and corresponding intensity, are part of the reason – along with exponential growth in participation – for the rise in soccer injuries.

Julie Nickoley of Storm soccer
Julie Nickoley came aboard as the Storm’s first head athletic trainer last April.

These increases are why the Colorado Storm Soccer Association (CSSA), one of the state’s oldest and largest youth soccer clubs, is teaming up with University of Colorado Sports Medicine specialists and UCHealth to provide on-field and off-field care for its athletes. This partnership gives young athletes access to leading sports medicine physicians with the experience and expertise in treating sports-related injuries. CU Sports Medicine specialists primarily provide care for athletes at UCHealth and Children’s Hospital Colorado facilities.

On-call for athletes, parents

In addition to providing physician care, CU Sports Medicine has hired Julie Nickoley, MA, ATC, as the full-time head athletic trainer at Colorado Storm to staff all home activities and travel with teams. While the job is immense – Colorado Storm encompasses 7,000 athletes, both competitive and recreation, playing in four regions along the Front Range – Nickoley provides care during practices, games and is on-call for athletes and parents.

When staffing home games, Nickoley is responsible for all players on the field, including athletes from visiting clubs. “For large tournaments, we can have 50 games in one day and I’m tasked with care for all players,” she explains. “Sometimes, we bring in trainers to help with volume because it’s extremely uncommon for a team to travel with an athletic trainer.” That, however, is not the case for Colorado Storm. So far, Nickoley has traveled twice with the Elite Club National League (ECNL) 14- to 18-year-old girls’ team, both times to San Diego.

A traveling athletic trainer is invaluable to the athletes, according to Caitlin McPherson, Colorado Storm goalkeeper. “Having a trainer who knows you personally, who knows the injury you’ve dealt with in the past or how to tape your ankle just right, is much more comforting than having someone you’ve never met doing the tape.”

‘There’s someone there’

Nickoley has treated a variety of injuries on the field including dislocated kneecaps, labral hip tears and sprained ankles. However, treatment doesn’t stop on the field. Nickoley further develops the home rehab plan, recommending exercises and stretches, and follows up on the player’s progress. Nickoley has also established an athletic training evaluation space inside the Colorado Storm headquarters available to athletes and parents. Having a dedicated space gives her the ability to see injuries within 48 hours, as well as provide treatment or taping before practice.

Storm soccer at Dove Valley Regional Park
The soccer fields at Dove Valley Regional Park fill up with Storm matches every weekend in the fall.

For athletes, the presence of an athletic trainer takes away the worry of injury. “It’s comforting to know if anything happens, there’s someone there, who knows what to look for, checking the player out,” says Caitlin. “Best case, the player gets checked and is cleared to return to play.”

In the event of a more serious injury, Nickoley’s close working relationship with CU Sports Medicine specialists has afforded her the ability to refer athletes and their parents to the most appropriate specialist depending on location, severity, or type of injury. She is currently working on an initiative to ensure Colorado Storm athletes have priority when the injury requires an X-ray, MRI or other procedure. This is the same approach CU Sports Medicine takes with collegiate level teams and the professional teams they support.

Concussion protocol

When she sees more serious concussions, Nickoley refers players to the CU Sports Medicine specialists at Children’s Hospital Colorado, which has a comprehensive concussion program. Nickoley has seen about 25 concussions in the last six months. She takes the injury very seriously, running through a 22-symptom list of concussion-related symptoms with players.  “I take the more conservative route – if you have two of those symptoms, it’s a concussion,” she says. In the case of a mild concussion, she tells the player, “You’re done for the day, and we’re going to wait 24 hours and then re-evaluate to see where you’re at.”

Soccer organizations are also addressing the problem through greater use of athletic trainers, such as Nickoley, as well as through rule changes. U.S. Soccer, the sport’s governing body, has told youth organizations that there should be no heading of the ball for players age 10 and under, while limiting the amount of heading during practice for ages 11 to 13.

Another benefit of having a full-time athletic trainer embedded in Colorado Storm is education on injury prevention techniques. Nickoley is working with coaches on a few specialized exercises that help decrease risks of anterior cruciate ligament (ACL) injury in girls, who are anatomically more predisposed to these injuries. She also consults with the coaches on nutrition, hydration, recovery, flexibility, and proper warm-up and cool-down so that athletes are conditioned for the high level of play.

Nickoley is only six months into the five-year partnership between CU Sports Medicine and Colorado Storm but well on her way to building a comprehensive care program for the young athletes. “There’s still work to be done. Ideally, we want to have programming for all regions of Colorado Storm,” she says. Right now, she’ll continue to focus her efforts on current players and game-day activities. Exceptional care, at all times, is what CU Sports Medicine specialists offer their Colorado Storm athletes.

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